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Use of buspirone for treatment of cerebellar ataxia. An open-label study.

AbstractOBJECTIVE:
To evaluate the efficacy of buspirone hydrochloride, a serotonin (5-hydroxytryptamine1A) agonist, in treating patients with cerebellar ataxia.
DESIGN:
Open-label study in which 20 patients (14 with cerebellar cortical atrophy and six with olivopontocerebellar atrophy) received buspirone hydrochloride, up to 60 mg/d, for 8 weeks.
SETTING:
Research hospital.
MAIN OUTCOME MEASURES:
Clinical, physiological, and psychological assessment.
RESULTS:
Nine patients with mild or moderate cerebellar dysfunction who completed the study showed significant improvement in clinical and self-assessment ratings, but not in a motor performance test, posturography (data were incomplete), State-Trait Anxiety Inventory, and Beck Depression Inventory. Seven patients with severe cerebellar dysfunction who completed the study had no improvement on any measure.
CONCLUSIONS:
Buspirone may be effective in treating mild to moderate cerebellar ataxia. A double-blind study of the efficacy of buspirone in cerebellar ataxia is warranted.
AuthorsJ S Lou, L Goldfarb, L McShane, P Gatev, M Hallett
JournalArchives of neurology (Arch Neurol) Vol. 52 Issue 10 Pg. 982-8 (Oct 1995) ISSN: 0003-9942 [Print] United States
PMID7575226 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Anti-Anxiety Agents
  • Serotonin Receptor Agonists
  • Buspirone
Topics
  • Adult
  • Aged
  • Anti-Anxiety Agents (therapeutic use)
  • Anxiety (drug therapy)
  • Buspirone (adverse effects, therapeutic use)
  • Cerebellar Ataxia (drug therapy, psychology)
  • Depression (drug therapy)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Psychomotor Performance
  • Self-Assessment
  • Serotonin Receptor Agonists (therapeutic use)

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