Carbimazole-induced agranulocytosis treated with granulocyte-macrophage colony stimulating factor--a case report.

Abstract

Drug-induced agranulocytosis is a potentially fatal complication despite advances in supportive care. A patient with carbimazole-induced agranulocytosis associated with marked depletion of granulocytic precursors in the marrow was treated with granulocyte-macrophage colony stimulating factor (GM-CSF) at a dose of 5 micrograms/kg subcutaneously daily for one week. The absolute neutrophil count rose above 1 x 10(9)/L after one week of GM-CSF therapy. The GM-CSF probably expedited the recovery of the neutrophil count. Further studies are warranted to delineate the role of GM-CSF in the treatment of drug-induced agranulocytosis.

• Authors: S C Ng
• Journal: Annals of the Academy of Medicine, Singapore (Ann Acad Med Singap) Vol. 24 Issue 3 Pg. 465-6 (May 1995) ISSN: 0304-4602 [Print] Singapore
• PMID: 7574435 (Publication Type: Case Reports, Journal Article)

Chemical References

• Granulocyte-Macrophage Colony-Stimulating Factor
• Carbimazole

Topics

• Agranulocytosis (chemically induced, therapy)
• Carbimazole (adverse effects)
• Female
• Granulocyte-Macrophage Colony-Stimulating Factor (administration & dosage, therapeutic use)
• Humans
• Leukocyte Count
• Middle Aged
• Neutrophils