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Drug treatment in children with juvenile rheumatoid arthritis. Past, present, and future.

Abstract
Rheumatology made its debut as a legitimate subspecialty of pediatrics sometime in the 1940s in Europe, and in the 1970s in North America. Therapy of juvenile rheumatoid arthritis has evolved from salicylates and gold injections to newer, less toxic nonsteroidal anti-inflammatory drugs and methotrexate. Corticosteroids remain as important drugs when life-threatening complications or blinding iridocyclitis develop. Immune response modifiers and gene therapies offer considerable potential for eventually halting or curing the disease but have yet to make a substantial impact on therapy. Methods for the correct conduct and interpretation of data from clinical trials are discussed.
AuthorsE H Giannini, G D Cawkwell
JournalPediatric clinics of North America (Pediatr Clin North Am) Vol. 42 Issue 5 Pg. 1099-125 (Oct 1995) ISSN: 0031-3955 [Print] United States
PMID7567188 (Publication Type: Historical Article, Journal Article, Review)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
Topics
  • Anti-Inflammatory Agents, Non-Steroidal (history, therapeutic use)
  • Antirheumatic Agents (history, therapeutic use)
  • Arthritis, Juvenile (drug therapy, history, therapy)
  • Child
  • Genetic Therapy
  • History, 20th Century
  • Humans
  • Rheumatology (history)

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