Beneficial effects of H290/51, a new lipid peroxidation inhibitor, on functional recovery after ischemia and reperfusion in isolated cold-arrested rat hearts.

Abstract

Lipid peroxidation is one of the major mechanisms involved in free radical-mediated postischemic myocardial injury. In the present study, a newly synthetized lipid peroxidation inhibitor H290/51 [cis-7methyl-9-methoxy-5,5a,b,10b- tetrahydroindeno(2,1-6 indole)] was evaluated for its effects on myocardial functional recovery during reperfusion after 30-min global ischemia in isolated cold-arrested rat hearts. Administration of 200 and 800 nM H290/51 at initiation of global ischemia markedly improved the functional recovery, whereas 50 nM H290/51 had no significant effects. The percent recovery of cardiac output (CO), left ventricular developed pressure (LVDP), and LVdP/dtmax at the end of the 30-min reperfusion period in the working mode was much higher in the groups receiving 200 and 800 nM H290/51 than that in vehicle group (CO 73 +/- 5 and 60 +/- 5 vs. 23 +/- 7%; LVDP 79 +/- 5 and 73 +/- 8 vs. 43 +/- 10%; LV dP/dtmax 78 +/- 5 and 69 +/- 4 vs. 45 +/- 10%). The indenoindole compound H290/51 reduced ischemia/reperfusion-induced cardiac dysfunction.

• Authors: Q D Wang, Y Uriuda, X S Li, R Nordlander, P O Sjöquist, L Rydén
• Journal: Journal of cardiovascular pharmacology (J Cardiovasc Pharmacol) Vol. 25 Issue 6 Pg. 924-9 (Jun 1995) ISSN: 0160-2446 [Print] United States
• PMID: 7564337 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• H290-51
• Indoles

Topics

• Analysis of Variance
• Animals
• Antioxidants (administration & dosage, pharmacology, therapeutic use)
• Blood Pressure (drug effects)
• Cardiac Output (drug effects)
• Heart (drug effects)
• In Vitro Techniques
• Indoles (administration & dosage, pharmacology, therapeutic use)
• Lipid Peroxidation (drug effects)
• Male
• Myocardial Reperfusion Injury (drug therapy)
• Rats
• Rats, Sprague-Dawley
• Ventricular Function, Left (drug effects)