[Granulomatous tubulointerstitial nephritis--Wegener's granulomatosis, sarcoidosis].

Abstract

Typical renal histological findings of Wegener's granulomatosis (WG) indicate a pauciimmune focal necrotizing glomerulonephritis with periglomerular granuloma and marked inflammatory cell infiltration in the interstitium. The recognition of the association between C (proteinase-3) anti-neutrophil cytoplasmic antibody (C [PR-3] ANCA) and WG is the only tool available to aid in the assessment of disease activity. Stage adapted immunosuppressive therapy (glucocorticoids and cyclophosphamide) has significantly altered the outcome of this once fatal disease. There are four categories of renal disease in Sarcoidosis (SD). 1) renal changes by abnormal calcium metabolism, 2) interstitial nephritis or granulomatous nephritis, 3) glomerulonephritis and 4) renal vasculitis. Corticosteroid therapy yield a favorable outcome for interstitial granulomatous nephritis of SD.

• Authors: M Yoshida
• Journal: Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 53 Issue 8 Pg. 1974-80 (Aug 1995) ISSN: 0047-1852 [Print] Japan
• PMID: 7563637 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Antibodies, Antineutrophil Cytoplasmic
• Autoantibodies
• Prednisolone

Topics

• Antibodies, Antineutrophil Cytoplasmic
• Autoantibodies (analysis)
• Granulomatosis with Polyangiitis (diagnosis, drug therapy)
• Humans
• Kidney (pathology)
• Prednisolone (administration & dosage)
• Sarcoidosis (diagnosis, drug therapy)