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Use of norfloxacin for prevention of symptomatic urinary tract infection in chronically catheterized patients.

Abstract
Thirty-four elderly inpatients with long-term urethral catheters were randomly assigned to receive either norfloxacin (200 mg/day) or placebo in a double-blind study with cross-over after three months. Twenty-three patients completed the entire study. Norfloxacin treatment was associated with a persistent decrease in gram-negative isolates (p < 0.005) and the acquisition of gram-positive norfloxacin-resistant flora. It also resulted in a highly statistically significant reduction of symptomatic urinary tract infections (1 vs. 12, p < 0.02), a decrease in catheter-associated local complications, obstructions and leakage (p < 0.05) and an improvement in the patients' general condition (p < 0.001). In conclusion, within the conditions of the present study, long-term suppression of gram-negative bacteriuria by norfloxacin reduced the incidence of catheter-related urinary tract infection and associated morbidity.
AuthorsO T Rutschmann, A Zwahlen
JournalEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (Eur J Clin Microbiol Infect Dis) Vol. 14 Issue 5 Pg. 441-4 (May 1995) ISSN: 0934-9723 [Print] Germany
PMID7556234 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Infective Agents
  • Norfloxacin
Topics
  • Aged
  • Aged, 80 and over
  • Anti-Infective Agents (administration & dosage, therapeutic use)
  • Antibiotic Prophylaxis
  • Bacterial Infections (etiology, prevention & control)
  • Cross-Over Studies
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Norfloxacin (administration & dosage, therapeutic use)
  • Treatment Outcome
  • Urinary Catheterization (adverse effects)
  • Urinary Tract Infections (etiology, physiopathology, prevention & control)

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