Abstract |
Thirty-four elderly inpatients with long-term urethral catheters were randomly assigned to receive either norfloxacin (200 mg/day) or placebo in a double-blind study with cross-over after three months. Twenty-three patients completed the entire study. Norfloxacin treatment was associated with a persistent decrease in gram-negative isolates (p < 0.005) and the acquisition of gram-positive norfloxacin-resistant flora. It also resulted in a highly statistically significant reduction of symptomatic urinary tract infections (1 vs. 12, p < 0.02), a decrease in catheter-associated local complications, obstructions and leakage (p < 0.05) and an improvement in the patients' general condition (p < 0.001). In conclusion, within the conditions of the present study, long-term suppression of gram-negative bacteriuria by norfloxacin reduced the incidence of catheter-related urinary tract infection and associated morbidity.
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Authors | O T Rutschmann, A Zwahlen |
Journal | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
(Eur J Clin Microbiol Infect Dis)
Vol. 14
Issue 5
Pg. 441-4
(May 1995)
ISSN: 0934-9723 [Print] Germany |
PMID | 7556234
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Infective Agents
- Norfloxacin
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Topics |
- Aged
- Aged, 80 and over
- Anti-Infective Agents
(administration & dosage, therapeutic use)
- Antibiotic Prophylaxis
- Bacterial Infections
(etiology, prevention & control)
- Cross-Over Studies
- Double-Blind Method
- Female
- Humans
- Male
- Norfloxacin
(administration & dosage, therapeutic use)
- Treatment Outcome
- Urinary Catheterization
(adverse effects)
- Urinary Tract Infections
(etiology, physiopathology, prevention & control)
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