Endotoxin-induced liver injury and changes in the levels of plasma tumor necrosis factor-alpha and interleukin-6 in rabbits.

Abstract

ELISA was employed to detect changes in plasma TNF-alpha and IL-6 level in rabbits having endotoxin-induced generalized Shwartzman reaction. Liver injury was assessed by the increase of serum ALT and hepatic histopathologic changes. The results showed that plasma TNF-alpha and IL-6 levels increased remarkably 12h after intravenous injection of endotoxin twice at a 24h interval, and these changes corresponded with the degree of liver injury. Coinjection of dexamethasone and endotoxin partly prevented the elevation of TNF-alpha and IL-6 levels and reduced liver injury. These results indicated that TNF-alpha and IL-6 were involved in endotoxin-induced liver injury.

• Authors: C Wu, M Li, C Chen, M Zhang
• Journal: Chinese medical journal (Chin Med J (Engl)) Vol. 108 Issue 7 Pg. 548-50 (Jul 1995) ISSN: 0366-6999 [Print] China
• PMID: 7555277 (Publication Type: Journal Article)

Chemical References

• Endotoxins
• Interleukin-6
• Tumor Necrosis Factor-alpha

Topics

• Animals
• Chemical and Drug Induced Liver Injury
• Endotoxins
• Escherichia coli
• Interleukin-6 (blood)
• Liver (pathology)
• Liver Diseases (blood)
• Male
• Necrosis
• Rabbits
• Tumor Necrosis Factor-alpha (metabolism)