Pingyangmycin as a 99mTc carrier in tumor localization.

Abstract

A simple method of preparation of 99mTc-pingyangmycin (PYM) for clinical use has been established using super-micro-amounts of SnCl2 as a reductant under dark conditions. The labeling efficiency was higher than 96%, and further purification was not necessary. The effect of ascorbic acid on the distribution of 99mTc-PYM had been investigated. Ascorbic acid increased uptake of 99mTc-PYM in the tumor. Tumor uptake increased with increasing concentration of ascorbic acid. Tumor-blood, tumor-liver, tumor-lung ratios at 1.5 h after 99mTc-PYM administration were 5.19 +/- 1.64, 2.71 +/- 0.51 and 4.15 +/- 0.57, respectively. Preliminary clinical trials in nine patients showed that 99mTc-PYM is a potentially useful tracer for tumor detection with good sensitivity and specificity (true positive 7/7, true negative 1/1, and false positive 1/1).

• Authors: T Huang, Y Zhang, J Wang, J Huang, D Liu, S Mong
• Journal: Nuclear medicine and biology (Nucl Med Biol) Vol. 22 Issue 4 Pg. 537-42 (May 1995) ISSN: 0969-8051 [Print] United States
• PMID: 7550032 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Organotechnetium Compounds
• technetium Tc 99m pingyangmycin
• Bleomycin
• Technetium
• zhengguangmycin

Topics

• Aged
• Animals
• Antibiotics, Antineoplastic (pharmacokinetics)
• Bleomycin (analogs & derivatives, chemistry, pharmacokinetics)
• Carcinoma, Ehrlich Tumor (diagnostic imaging, metabolism)
• Carcinoma, Squamous Cell (diagnostic imaging, pathology)
• Drug Stability
• Female
• Humans
• Isotope Labeling (methods)
• Lung Neoplasms (diagnostic imaging, pathology)
• Male
• Mice
• Mice, Inbred Strains
• Middle Aged
• Organotechnetium Compounds (chemistry, pharmacokinetics)
• Radiography
• Radionuclide Imaging
• Technetium (pharmacokinetics)
• Tissue Distribution