Ciprofloxacin ophthalmic solution versus rifamycin ophthalmic solution for the treatment of conjunctivitis and blepharitis.

Abstract	The efficacy and safety of ciprofloxacin (0.3%) ophthalmic solution and rifamycin (1%) ophthalmic solution for the treatment of bacterial conjunctivitis and blepharitis was compared in this randomized, double-masked, parallel-group study. Forty-one patients, 19 on ciprofloxacin and 22 on rifamycin, were culture-positive on admission and evaluated for efficacy. There was clinical improvement in more than 90% of patients in each group at the end of the seven-day treatment period. However, clinical cure rates on day 7 appeared to be higher with ciprofloxacin (53%) than rifamycin (23%; p = 0.061, Mann-Whitney test). Bacteriological eradication rates were comparable: the infecting organisms were eradicated in 68% of patients on ciprofloxacin and 77% with rifamycin. There were no serious adverse reactions to either treatment. One patient in each group was withdrawn on account of a mild allergy. In conclusion, topical ciprofloxacin was effective and well tolerated and would be a particularly useful agent for the treatment of bacterial conjunctivitis and blepharitis.
Authors	J P Adenis, J Colin, P Verin, P Saint-Blancat, F Malet
Journal	European journal of ophthalmology (Eur J Ophthalmol) 1995 Apr-Jun Vol. 5 Issue 2 Pg. 82-7 ISSN: 1120-6721 [Print] United States
PMID	7549447 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References	Ophthalmic Solutions Rifamycins Ciprofloxacin
Topics	Acute Disease Administration, Topical Adolescent Adult Aged Aged, 80 and over Bacteria (drug effects, isolation & purification) Blepharitis (drug therapy, microbiology) Child Chronic Disease Ciprofloxacin (adverse effects, therapeutic use) Conjunctiva (microbiology) Conjunctivitis, Bacterial (drug therapy, microbiology) Double-Blind Method Drug Tolerance Eye Infections, Bacterial (drug therapy) Eyelids (microbiology) Female Humans Male Middle Aged Ophthalmic Solutions Rifamycins (adverse effects, therapeutic use) Treatment Outcome

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