HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Age-response effectiveness of gallopamil for the treatment of myocardial exertional ischemia. A medium-term randomized cross-over double-blind placebo-controlled trial.

Abstract
We evaluated the efficacy and safety of gallopamil 150 mg daily in middle-aged and elderly patients with stable exertional ischemia, using a medium-term randomized double-blind cross-over placebo-controlled trial. Twenty middle-aged patients (52.8 +/- 6 years; range 38-61 years) and 14 elderly patients (67.4 +/- 2.8 years; range 65-73 years) with stable exertional ischemia underwent a bicycle exercise test. After a run-in period, both groups received treatment with either placebo or gallopamil 50 mg tid for 28 days. At the end of this time, each patient crossed over to the alternate regimen. Gallopamil significantly reduced heart rate, blood pressure and rate pressure product (from 15.37 +/- 2.7 to 13.65 +/- 4.16 U x 10(-3); p < 0.01) in elderly patients at submaximal exercise, but had no effect in middle-aged patients (from 14.52 +/- 4.45 to 13.49 +/- 3.77 U x 10(-3); p = NS). At peak exercise, none of the hemodynamic parameters was modified with gallopamil in either group. At peak exercise, both middle-aged and elderly patients achieved rate-pressure products similar to those reached during placebo at higher work loads. Exercise duration and maximal work load significantly increased in both groups. Electrocardiographic signs of ischemia were favorably influenced by gallopamil in both groups (from 1.39 +/- 0.5 mm to 0.76 +/- 0.73 mm; p < 0.001 in the middle-aged patients and from 1.5 +/- 0.34 mm to 1 +/- 0.76 mm; p < 0.01 in the elderly patients).(ABSTRACT TRUNCATED AT 250 WORDS)
AuthorsD Acanfora, L Odierna, L De Caprio, G Longobardi, C Rengo, N Guerra, G Furgi, O F Bollella, C Picone, F Rengo
JournalAging (Milan, Italy) (Aging (Milano)) Vol. 7 Issue 2 Pg. 150-6 (Apr 1995) ISSN: 0394-9532 [Print] Italy
PMID7548266 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Placebos
  • Vasodilator Agents
  • Gallopamil
Topics
  • Adult
  • Age Distribution
  • Aged
  • Angiography
  • Coronary Circulation (drug effects)
  • Cross-Over Studies
  • Double-Blind Method
  • Exercise Test
  • Female
  • Gallopamil (therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Myocardial Ischemia (drug therapy)
  • Physical Exertion
  • Placebos
  • Reproducibility of Results
  • Single-Blind Method
  • Vasodilator Agents (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: