Abstract |
We observed apparent hypoglycemia in seven patients manifesting granulocytosis associated with hematopoietic cytokine treatment or with a leukemoid reaction. All seven patients had confounding preanalytic conditions of specimen transport delay and lack of antiglycolytic agents. Cytokine-stimulated leukocytes may cause artifactual hypoglycemia by consuming glucose in vitro, possibly leading to unnecessary diagnostic evaluation. The glucose depletion was faster in blood drawn from patients receiving granulocyte colony-stimulating factor (0.29 mmol/L/h) than in blood from a control group (0.17 mmol/L/h) or from a group with leukemia (0.23 mmol/L/h). Stabilization with sodium fluoride (60 mmol/L) slowed the glucose depletion in both the cytokine group (0.13 mmol/L/h) and the leukemic group (0.09 mmol/L/h), which were then statistically indistinguishable from the control rate (0.10 mmol/L/h). In blood obtained from patients being treated with hematopoietic cytokines or who have leukemoid reactions, an antiglycolytic agent should be used whenever separation of plasma might be delayed more than 1 hour.
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Authors | J R Astles, W P Petros, W P Peters, F A Sedor |
Journal | Archives of pathology & laboratory medicine
(Arch Pathol Lab Med)
Vol. 119
Issue 8
Pg. 713-6
(Aug 1995)
ISSN: 0003-9985 [Print] United States |
PMID | 7544105
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Cytokines
- Granulocyte Colony-Stimulating Factor
- Fluorides
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Topics |
- Artifacts
- Cytokines
(adverse effects, physiology)
- Data Collection
- Fluorides
(pharmacology)
- Granulocyte Colony-Stimulating Factor
(adverse effects, therapeutic use)
- Hematopoiesis
- Humans
- Hypoglycemia
(epidemiology, etiology, prevention & control)
- Incidence
- Leukemia
(blood)
- Leukocytosis
(complications, epidemiology)
- Male
- Middle Aged
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