Abstract |
The salivary secretion and the histopathological effects after administration of a single dose of cis-2-methylspiro (1,3-oxathiolane-5,3') quinuclidine hydrochloride hemihydrate (SNI-2011) were monitored in adult, male and female MRL/lpr mice, C57BL/6J mice and ICR mice. SNI-2011 (1-10 mg/kg, i.p.), dose-dependently increased the secretion of saliva in MRL/lpr mice. The flow rate decreased gradually over the course of 60 min. The total volume of saliva, secreted in response to SNI-2011, was significantly higher in male than in female MRL/lpr mice, but there was no significant difference in this parameter between male and female C57BL/6J and ICR mice. Degeneration, apparent as atrophy and necrosis of serous cells in MRL/lpr mice, was reversed by treatment with SNI-2011 (3 and 6 mg/kg). These results suggest that SNI-2011 could be useful in the treatment of xerostomia in patients with Sjögren's syndrome.
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Authors | Y Iwabuchi, M Katagiri, T Masuhara |
Journal | Archives internationales de pharmacodynamie et de therapie
(Arch Int Pharmacodyn Ther)
1994 Nov-Dec
Vol. 328
Issue 3
Pg. 315-25
ISSN: 0003-9780 [Print] Belgium |
PMID | 7542865
(Publication Type: Journal Article)
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Chemical References |
- Parasympathomimetics
- Quinuclidines
- Thiophenes
- cevimeline
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Topics |
- Animals
- Autoimmune Diseases
(physiopathology)
- Dose-Response Relationship, Drug
- Female
- Injections, Intraperitoneal
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred ICR
- Parasympathomimetics
(administration & dosage, toxicity)
- Parotid Gland
(drug effects, metabolism, pathology)
- Quinuclidines
(administration & dosage, toxicity)
- Saliva
(metabolism)
- Salivary Glands
(drug effects, metabolism, pathology)
- Sex Factors
- Species Specificity
- Staining and Labeling
- Sublingual Gland
(drug effects, metabolism, pathology)
- Submandibular Gland
(drug effects, metabolism, pathology)
- Thiophenes
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