Abstract | PURPOSE: MATERIALS AND METHODS: We randomized 149 patients to undergo androgen deprivation and 138 to undergo lymphadenectomy with (137) or without (1) prostatectomy. Of the 154 patients randomized to the surgery alone group 144 underwent pelvic node dissection with (138) or without (6) prostatectomy. RESULTS: There was no statistically significant difference between the 2 groups in operating time, blood loss, need for transfusion, postoperative morbidity or length of hospital stay. There were 4 rectal and 2 ureteral injuries in the surgery alone group and none in the pretreatment group (p < 0.05). Patients who received androgen deprivation preoperatively had a significantly lower rate of capsule penetration (47% versus 78%, p < 0.001), positive surgical margins (18% versus 48%, p < 0.001) and tumor at the urethral margin (6% versus 17%, p < 0.01). CONCLUSIONS: Long-term followup data will be needed to determine whether there will be a lower incidence of biochemical relapse as determined by prostate specific antigen, local recurrence or metastasis, with an improvement in patient survival.
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Authors | M S Soloway, R Sharifi, Z Wajsman, D McLeod, D P Wood Jr, A Puras-Baez |
Journal | The Journal of urology
(J Urol)
Vol. 154
Issue 2 Pt 1
Pg. 424-8
(Aug 1995)
ISSN: 0022-5347 [Print] United States |
PMID | 7541859
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Flutamide
- Prostate-Specific Antigen
- Leuprolide
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Topics |
- Aged
- Combined Modality Therapy
- Flutamide
(therapeutic use)
- Follow-Up Studies
- Humans
- Leuprolide
(therapeutic use)
- Male
- Middle Aged
- Neoplasm Metastasis
- Neoplasm Staging
- Preoperative Care
- Prospective Studies
- Prostate-Specific Antigen
(blood)
- Prostatectomy
(methods)
- Prostatic Neoplasms
(blood, drug therapy, pathology, surgery)
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