Abstract |
The effect of (-) eburnamonine, papaverine and UDP-glucose intracarotid perfusion has been evaluated in the brain of beagle dogs during various conditions of cerebral damage ( hypoxia, hypoxia plus incomplete ischaemia, hypoxia plus complete ischaemia), and after 3, 15 or 30 min of the post-hypoxic recovery and recirculation. The behaviour of fuels ( glycogen, glucose), of glycolytic pathway intermediates (glucose-6-phosphate, pyruvate) and end-product ( lactate), of the pool of labile phosphates ( ATP, ADP, AMP, creatine phosphate) and the energy charge potential of the brain were evaluated in the motor area of the cerebral cortex. The different pharmacological effects of (-) eburnamonine, papaverine and UDP-glucose are discussed with regard to the biochemical changes taking place during the physiopathological conditions tested.
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Authors | R F Villa, P Strada, F Marzatico, F Dagani |
Journal | European neurology
(Eur Neurol)
Vol. 17 Suppl 1
Pg. 97-112
( 1978)
ISSN: 0014-3022 [Print] Switzerland |
PMID | 753643
(Publication Type: Journal Article)
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Chemical References |
- Lactates
- Pyruvates
- Uridine Diphosphate Sugars
- Vasodilator Agents
- Vinca Alkaloids
- Phosphocreatine
- Adenosine Monophosphate
- Adenosine Diphosphate
- Adenosine Triphosphate
- Glycogen
- Papaverine
- Glucose
- Uridine Diphosphate Glucose
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Topics |
- Adenosine Diphosphate
(metabolism)
- Adenosine Monophosphate
(metabolism)
- Adenosine Triphosphate
(metabolism)
- Animals
- Brain
(metabolism)
- Brain Ischemia
(metabolism)
- Dogs
- Energy Metabolism
(drug effects)
- Female
- Glucose
(metabolism)
- Glycogen
(metabolism)
- Hypoxia, Brain
(metabolism)
- Lactates
(metabolism)
- Papaverine
(pharmacology)
- Phosphocreatine
(metabolism)
- Pyruvates
(metabolism)
- Uridine Diphosphate Glucose
(pharmacology)
- Uridine Diphosphate Sugars
(pharmacology)
- Vasodilator Agents
(pharmacology)
- Vinca Alkaloids
(pharmacology)
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