Abstract |
Solitary fibrous tumors (SFTs) often involve the pleura and also may encompass the peritoneum and nonserosal sites. On occasion SFTs mimics other neoplasms, including desmoplastic mesothelioma. CD-34, initially characterized as a hematopoietic progenitor cell antigen, recently has been identified in a small number of SFTs. Based on this observation, we compared the keratin, vimentin, and CD-34 expression of 19 SFTs and eight desmoplastic mesotheliomas. Fifteen of 19 SFTs (78.9%) expressed CD-34, whereas keratin expression was absent in all SFTs. In contrast, none of the desmoplastic mesotheliomas expressed CD-34 and keratin expression was found in seven of eight (87.5%). Vimentin expression was noted in 18 of 19 SFTs and in seven of eight desmoplastic mesotheliomas. We conclude that CD-34 expression distinguishes SFT from desmoplastic mesothelioma. Additionally, the results of our study support the idea that SFT is not derived from or related to conventional mesothelium.
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Authors | A Flint, S W Weiss |
Journal | Human pathology
(Hum Pathol)
Vol. 26
Issue 4
Pg. 428-31
(Apr 1995)
ISSN: 0046-8177 [Print] United States |
PMID | 7535740
(Publication Type: Journal Article)
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Chemical References |
- Antigens, CD
- Antigens, CD34
- Biomarkers, Tumor
- Vimentin
- Keratins
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Topics |
- Antigens, CD
(analysis)
- Antigens, CD34
- Biomarkers, Tumor
(analysis)
- Cell Nucleus
(pathology)
- Humans
- Keratins
(analysis)
- Mesothelioma
(pathology)
- Pleural Neoplasms
(pathology)
- Vimentin
(analysis)
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