Abstract |
High levels of von Willebrand factor (vWF) have been reported in diabetics with vascular complications, suggesting a role for this protein in the development of cardiovascular complications in non-insulin-dependent diabetes mellitus ( NIDDM). Recently, a diet rich in monounsaturated fatty acids (MUFA) has been found to improve glycemic control and decrease diurnal blood pressure as compared with a high- carbohydrate (H-CHO) diet in NIDDM subjects. To study the impact of MUFA on the hemostatic system, we compared the levels of vWF, fibrinogen, fibronectin, and alpha 2-macroglobulin before and after 3 weeks on a high-MUFA (H-MUFA) diet and on an isocaloric H-CHO diet in 15 NIDDM subjects. In a crossover study, the patients were randomly assigned to a H-CHO diet (50% carbohydrate, 30% fat [10% MUFA]) or a H-MUFA diet (30% carbohydrate, 50% fat [30% MUFA]). Before and on the last day of the two diets, vWF, fibrinogen, fibronectin, and alpha 2-macroglobulin levels were measured. The H-MUFA diet caused a decrease in vWF from 1.31 +/- 0.08 to 1.13 +/- 0.08 U/mL (P < .004), whereas an unchanged level was observed after a H-CHO diet (1.19 +/- 0.11 v 1.25 +/- 0.11 U/mL, NS). The relative changes in vWF during 3 weeks on a H-MUFA and on a H-CHO diet attained -12.5% +/- 3.2% versus 5.7% +/- 3.5%, respectively (P < .0001). Furthermore, unchanged levels of fibrinogen, fibronectin, and alpha 2-macroglobulin were seen after usage of the two diets.(ABSTRACT TRUNCATED AT 250 WORDS)
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Authors | O Rasmussen, C Thomsen, J Ingerslev, K Hermansen |
Journal | Metabolism: clinical and experimental
(Metabolism)
Vol. 43
Issue 11
Pg. 1406-9
(Nov 1994)
ISSN: 0026-0495 [Print] United States |
PMID | 7526126
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dietary Carbohydrates
- Dietary Fats, Unsaturated
- Fatty Acids, Monounsaturated
- Fibronectins
- alpha-Macroglobulins
- von Willebrand Factor
- Fibrinogen
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Topics |
- Cross-Over Studies
- Diabetes Mellitus, Type 2
(blood, complications, diet therapy)
- Diabetic Angiopathies
(blood, etiology, prevention & control)
- Dietary Carbohydrates
(administration & dosage)
- Dietary Fats, Unsaturated
(administration & dosage)
- Endothelium, Vascular
(drug effects)
- Fatty Acids, Monounsaturated
(administration & dosage)
- Female
- Fibrinogen
(analysis)
- Fibronectins
(analysis)
- Humans
- Male
- Middle Aged
- alpha-Macroglobulins
(analysis)
- von Willebrand Factor
(analysis)
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