Abstract |
A 31 year-old male with refractory immune thrombocytopenic purpura ( ITP) was accompanied with avascular necrosis of the femoral head on both sides, refractory to the following conventional therapies: high dose immunoglobulin ( IgG) therapy, splenectomy, vinblastin slow infusion; maintaining a platelet count less than 20 x 10(3)/microliters. He subsequently tried the combination of high dose IgG therapy with platelet transfusion from two single donors, which successfully increased the platelet count to more than 50 x 10(3)/microliters for as long as 9 days. Compared to this method, platelet transfusion alone without IgG infusion failed to maintain an increase in the platelet count. These results suggest that high dose IgG may affect transfused-platelet removal in ITP. Management by the combination method enabled him to undergo surgery twice and he was able to walk with a stick six months later.
|
Authors | M Katoh, K Shikoshi, T Kosuge, M Umeda, T Tsukahara |
Journal | [Rinsho ketsueki] The Japanese journal of clinical hematology
(Rinsho Ketsueki)
Vol. 35
Issue 8
Pg. 798-800
(Aug 1994)
ISSN: 0485-1439 [Print] Japan |
PMID | 7523744
(Publication Type: Case Reports, English Abstract, Journal Article)
|
Chemical References |
|
Topics |
- Adult
- Combined Modality Therapy
- Femur Head Necrosis
(surgery)
- Humans
- Male
- Platelet Transfusion
- Purpura, Thrombocytopenic, Idiopathic
(complications, therapy)
- gamma-Globulins
(administration & dosage)
|