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[Refractory immune thrombocytopenic purpura accompanied with avascular necrosis of femoral head receiving the combination of high dose immunoglobulin therapy followed by platelet transfusion could successfully be managed to undergo surgery].

Abstract
A 31 year-old male with refractory immune thrombocytopenic purpura (ITP) was accompanied with avascular necrosis of the femoral head on both sides, refractory to the following conventional therapies: high dose immunoglobulin (IgG) therapy, splenectomy, vinblastin slow infusion; maintaining a platelet count less than 20 x 10(3)/microliters. He subsequently tried the combination of high dose IgG therapy with platelet transfusion from two single donors, which successfully increased the platelet count to more than 50 x 10(3)/microliters for as long as 9 days. Compared to this method, platelet transfusion alone without IgG infusion failed to maintain an increase in the platelet count. These results suggest that high dose IgG may affect transfused-platelet removal in ITP. Management by the combination method enabled him to undergo surgery twice and he was able to walk with a stick six months later.
AuthorsM Katoh, K Shikoshi, T Kosuge, M Umeda, T Tsukahara
Journal[Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 35 Issue 8 Pg. 798-800 (Aug 1994) ISSN: 0485-1439 [Print] Japan
PMID7523744 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • gamma-Globulins
Topics
  • Adult
  • Combined Modality Therapy
  • Femur Head Necrosis (surgery)
  • Humans
  • Male
  • Platelet Transfusion
  • Purpura, Thrombocytopenic, Idiopathic (complications, therapy)
  • gamma-Globulins (administration & dosage)

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