KP-1: not a specific marker. Staining of 137 sarcomas, 48 lymphomas, 28 carcinomas, 7 malignant melanomas and 8 cystosarcoma phyllodes.

Abstract

This study documents the reactions of the monoclonal antibody KP-1, which detects histiocytes in paraffin sections, with 137 sarcomas, 48 lymphomas, 28 carcinomas, 7 malignant melanomas and 8 cystosarcoma phyllodes. The soft tissue sarcomas had been previously immunophenotyped. Positive staining was obtained in all categories of sarcoma except clear-cell sarcomas. Most categories of sarcoma showed staining in less than 10% of tumour cells although a minority of leiomyosarcomas showed more extensive staining. Five of 7 malignant melanomas were also positive while all lymphomas and carcinomas were negative. We conclude that KP-1 positivity is not helpful in supporting the histiocytic origin of a tumour and is of limited value in the differential diagnosis of soft tissue sarcomas or their separation from other categories of malignancy.

• Authors: M Cassidy, B Loftus, A Whelan, B Sabt, D Hickey, K Henry, M Leader
• Journal: Virchows Archiv : an international journal of pathology (Virchows Arch) Vol. 424 Issue 6 Pg. 635-40 ( 1994) ISSN: 0945-6317 [Print] Germany
• PMID: 7519954 (Publication Type: Journal Article, Review)

Chemical References

• Antigens, CD
• Antigens, Differentiation, Myelomonocytic
• Biomarkers, Tumor
• CD68 antigen, human

Topics

• Antigens, CD (analysis)
• Antigens, Differentiation, Myelomonocytic (analysis)
• Biomarkers, Tumor (analysis)
• Breast Neoplasms (chemistry)
• Carcinoma (chemistry)
• Female
• Humans
• Lymphoma (chemistry)
• Melanoma (chemistry)
• Phyllodes Tumor (chemistry)
• Sarcoma (chemistry)
• Soft Tissue Neoplasms (chemistry)
• Staining and Labeling