Circulating levels of insulin-like growth factor-I and -II, and IGF-binding protein-3 in inflammation and after parathyroid hormone infusion.

Abstract

In order to assess if the anabolic action of PTH is related to changes in circulating levels of insulin-like growth factor-I and -II (IGF-I and -II), and IGF binding protein 3 (IGFBP-3), 24 h of PTH infusion was performed in healthy women and in patients with rheumatoid arthritis (RA), a state where both bone metabolism and PTH secretion is influenced by the inflammatory activity. The patients with RA had lower basal levels of both IGF-I and -II than the healthy controls (P < 0.05). In neither group did the IGFs change after 24 h of PTH administration, while IGFBP-3 was significantly increased in the healthy controls (4600 +/- 1200 to 5750 +/- 2200 micrograms/l, P < 0.05). IGFBP-3 was not affected by PTH infusion in patients with RA when the disease had high activity, but when inflammation had subsided they responded with a similar increase in IGFBP-3 as the control group and basal IGF-I and -II levels were normalised. Since IGFBP-3 can enhance the anabolic action of IGF-I, increased IGFBP-3 levels after PTH infusion may reflect a mechanism by which PTH is anabolic for bone. Inflammation may inhibit bone formation via decreased serum levels of IGFs and blocked IGFBP-3 response to PTH.

• Authors: A G Johansson, D J Baylink, E af Ekenstam, E Lindh, S Mohan, S Ljunghall
• Journal: Bone and mineral (Bone Miner) Vol. 24 Issue 1 Pg. 25-31 (Jan 1994) ISSN: 0169-6009 [Print] Ireland
• PMID: 7514466 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carrier Proteins
• Insulin-Like Growth Factor Binding Proteins
• Parathyroid Hormone
• Peptide Fragments
• parathyroid hormone (1-38)
• Insulin-Like Growth Factor I
• Insulin-Like Growth Factor II
• Calcium

Topics

• Adult
• Aged
• Arthritis, Rheumatoid (blood)
• Bone and Bones (drug effects, metabolism)
• Calcium (blood)
• Carrier Proteins (blood)
• Female
• Humans
• Infusion Pumps
• Insulin-Like Growth Factor Binding Proteins
• Insulin-Like Growth Factor I (metabolism)
• Insulin-Like Growth Factor II (metabolism)
• Male
• Middle Aged
• Parathyroid Hormone (administration & dosage, pharmacology)
• Peptide Fragments (administration & dosage, pharmacology)