Abstract | BACKGROUND: PATIENTS AND METHODS: Fourteen patients with Waldenström's macroglobulinemia and prior exposure to fludarabine were treated with two courses of 2chlorodeoxyadenosine. RESULTS: Three out of four patients that had previously responded to fludarabine and were relapsing from unmaintained remission, achieved a partial response with 2chlorodeoxyadenosine therapy. However, only one out of 10 patients with disease resistant to fludarabine responded to 2chlorodeoxyadenosine. CONCLUSIONS: 2chlorodeoxyadenosine may be effective in patients with Waldenström macroglobulinemia sensitive to fludarabine. However, this compound has limited activity for patients with disease resistant to fludarabine.
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Authors | M A Dimopoulos, D M Weber, H Kantarjian, M Keating, R Alexanian |
Journal | Annals of oncology : official journal of the European Society for Medical Oncology
(Ann Oncol)
Vol. 5
Issue 3
Pg. 288-9
(Mar 1994)
ISSN: 0923-7534 [Print] England |
PMID | 7514439
(Publication Type: Journal Article)
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Chemical References |
- Antimetabolites, Antineoplastic
- Vidarabine Phosphate
- fludarabine phosphate
- Cladribine
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Topics |
- Aged
- Antimetabolites, Antineoplastic
(therapeutic use)
- Cladribine
(adverse effects, therapeutic use)
- Drug Resistance
- Female
- Humans
- Male
- Middle Aged
- Recurrence
- Treatment Outcome
- Vidarabine Phosphate
(analogs & derivatives, therapeutic use)
- Waldenstrom Macroglobulinemia
(drug therapy)
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