Abstract |
Hypertension is associated with a hypersensitive response to the Ca2+ channel activator, Bay K 8644. We investigated the effect of the endothelin ETA receptor antagonist, BQ-123, on the contractions induced by Bay K 8644 in aorta from spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats. BQ-123 (1 microM) decreased the sensitivity to Bay K 8644 of aorta of SHR down to that of WKY. This observation is consistent with a role for endothelin in hypertension.
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Authors | N Morel, T Godfraind |
Journal | European journal of pharmacology
(Eur J Pharmacol)
Vol. 252
Issue 2
Pg. R3-4
(Feb 03 1994)
ISSN: 0014-2999 [Print] Netherlands |
PMID | 7512502
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Calcium Channel Agonists
- Calcium Channel Blockers
- Endothelin Receptor Antagonists
- Peptides, Cyclic
- 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
- cyclo(Trp-Asp-Pro-Val-Leu)
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Topics |
- 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
(antagonists & inhibitors, pharmacology)
- Animals
- Aorta, Thoracic
(drug effects)
- Blood Pressure
(drug effects)
- Calcium Channel Agonists
(pharmacology)
- Calcium Channel Blockers
- Endothelin Receptor Antagonists
- In Vitro Techniques
- Isometric Contraction
(drug effects)
- Muscle, Smooth, Vascular
(drug effects)
- Peptides, Cyclic
(pharmacology)
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
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