Abstract |
Superfusion of capsaicin onto the serosal surface of jejunum of Nippostrongylus brasiliensis-sensitized rats induces a short-lasting (1-3 min), dose-dependent (2 to 20 micrograms) decrease in blood pressure which ranges from -5.3 +/- 1.4% to -22.6 +/- 2.2%. The hypotension evoked by capsaicin was more marked in sensitized rats than in unsensitized animals, which responded only to the highest dose (20 mg) of capsaicin tested. The hypotensive effects of capsaicin were not affected by intravenous injections of mepyramine (10 mg/kg), a histamine receptor antagonist, or by the cyclooxygenase inhibitor indomethacin (10 mg/kg). However, an intravenous injection of a platelet-activating factor (PAF) antagonist, BN 52021 (20 mg/kg), or an intraperitoneal injection of guanethidine (8 mg/kg) 18 h prior to experimentation, to functionally impair the sympathetic nerves, abolished the capsaicin-induced drop in blood pressure. Treatment of neonatal rats with capsaicin reduced by 75% the hypotensive effects of capsaicin, whereas the capsaicin antagonist, ruthenium red, reduced non-significantly the hypotensive action of capsaicin. It is concluded that the activation of jejunal sensory nerves in N. brasiliensis-sensitized rats by capsaicin induced a reflex hypotension that is dependent upon PAF release from mast cells and functional sympathetic nerves. In addition, the afferent function of the sensory nerves are not totally blocked by ruthenium red as capsaicin elicits the reflex hypotension in the presence of this blocker of sensory nerve efferent function.
|
Authors | R Mathison, J S Davison |
Journal | Naunyn-Schmiedeberg's archives of pharmacology
(Naunyn Schmiedebergs Arch Pharmacol)
Vol. 348
Issue 6
Pg. 638-42
(Dec 1993)
ISSN: 0028-1298 [Print] Germany |
PMID | 7510855
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Diterpenes
- Ginkgolides
- Lactones
- Platelet Activating Factor
- Ruthenium Red
- ginkgolide B
- Pyrilamine
- Capsaicin
- Indomethacin
- Guanethidine
|
Topics |
- Anaphylaxis
(physiopathology)
- Animals
- Animals, Newborn
- Blood Pressure
(drug effects)
- Capsaicin
(antagonists & inhibitors, pharmacology)
- Diterpenes
- Ginkgolides
- Guanethidine
(pharmacology)
- Hemodynamics
(drug effects)
- Indomethacin
(pharmacology)
- Jejunum
(drug effects, innervation, parasitology)
- Lactones
(pharmacology)
- Male
- Neurons, Afferent
(drug effects)
- Nippostrongylus
- Platelet Activating Factor
(antagonists & inhibitors)
- Pyrilamine
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Reflex
(drug effects)
- Ruthenium Red
(pharmacology)
- Strongylida Infections
(parasitology, physiopathology)
|