In vivo effect of chlorophyllin on gamma-ray-induced sister chromatid exchange in murine bone marrow cells.

Abstract

The aim of the present work is to determine the radioprotective capacity of chlorophyllin, by measuring the reduction of gamma-ray-induced sister-chromatid exchange (SCE) in murine bone marrow cells in vivo. The results obtained in two separate experiments, using 10, 50 and 100 micrograms of chlorophyllin per g of body weight (bw), indicate that chlorophyllin per se did not have any effect on the SCE frequency and that the dose of 100 micrograms/g bw protects 100% against the induction of SCE by 1.0 Gy of gamma-rays; 50 micrograms/g bw protects less than 50% and 10 micrograms/g bw affords no protection.

• Authors: P Morales-Ramírez, M C García-Rodríguez
• Journal: Mutation research (Mutat Res) Vol. 320 Issue 4 Pg. 329-34 (Mar 1994) ISSN: 0027-5107 [Print] Netherlands
• PMID: 7508558 (Publication Type: Journal Article)

Chemical References

• Antimutagenic Agents
• Chlorophyllides
• chlorophyllin

Topics

• Animals
• Antimutagenic Agents (administration & dosage, pharmacology)
• Body Weight
• Bone Marrow (radiation effects)
• Chlorophyllides (administration & dosage, pharmacology)
• Male
• Mice
• Mice, Inbred BALB C
• Sister Chromatid Exchange (drug effects)