Abstract |
Recently CYFRA 21-1, a new tumour marker measuring a fragment of cytokeratin 19, was introduced and proved to be suitable for the follow-up care and monitoring of the therapy of non-small cell lung carcinomas, especially squamous cell carcinomas of the lung. Besides CYFRA 21-1, there are two other tumour markers available, called tissue polypeptide antigen (TPA) and tissue polypeptide specific antigen (TPS), which also measure different cytokeratins in serum. In a retrospective study we investigated the clinical significance of these 3 cytokeratin markers in lung cancer compared with carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC) and neuron-specific enolase (NSE). We investigated the sera of 50 healthy persons, 273 patients with various benign diseases and 218 patients with histologically proven lung cancer. In a first step the specificity versus benign diseases of the lung was established for all the markers, and was fixed at 95%. Then the single and combined sensitivities were calculated. CYFRA 21-1 proved to possess the highest sensitivity in lung cancer in general (61%), in non-small cell lung carcinomas (64%), in squamous cell carcinomas (79%), in adenocarcinomas (54%) and in large cell carcinomas (65%). In small cell lung carcinomas, neuron-specific enolase proved again to be the marker of first choice (55%). Combined determinations proved clearly increased sensitivity only for large cell carcinomas ( CYFRA 21-1 + TPA: 77%) and for small cell lung carcinomas ( CYFRA 21-1 + NSE: 62%).(ABSTRACT TRUNCATED AT 250 WORDS)
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Authors | P Stieber, H Dienemann, U Hasholzner, C Müller, S Poley, K Hofmann, A Fateh-Moghadam |
Journal | European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies
(Eur J Clin Chem Clin Biochem)
Vol. 31
Issue 10
Pg. 689-94
(Oct 1993)
ISSN: 0939-4974 [Print] Germany |
PMID | 7507359
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antigens, Neoplasm
- Biomarkers, Tumor
- Peptides
- Tissue Polypeptide Antigen
- Keratins
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Topics |
- Antigens, Neoplasm
(blood)
- Biomarkers, Tumor
(blood)
- Female
- Gastrointestinal Diseases
(blood)
- Genital Diseases, Female
(blood)
- Humans
- Keratins
(blood)
- Lung Diseases
(blood)
- Lung Neoplasms
(blood, diagnosis)
- Male
- Peptides
(blood)
- Reference Values
- Retrospective Studies
- Sensitivity and Specificity
- Tissue Polypeptide Antigen
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