Abstract |
The ability of cytokines (IFN alpha, IFN gamma, TNF alpha, IL-1 alpha, IL-6), all-trans retinoic acid, 1,25(OH)2-vitamin D3 and the tumor promoting phorbol ester TPA to regulate cell surface expression of protectin ( CD59 antigen) on human hematopoietic and non-hematopoietic neoplastic cell lines was examined with the aid of immunocytofluorometric measurements. The tumor promoting phorbol ester TPA induced a marked up-regulation of protectin in all examined cell lines with the exception of promyelocytic leukemia HL-60, where TPA significantly decreased protectin cell surface expression. All-trans retinoic acid weakly down-regulated cell surface protectin on K-562, while 1,25(OH)2-vitamin D3 produced such effect on HL-60 cells. None of the examined cytokines induced a significant protectin down-regulation in the examined cell lines.
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Authors | J Sedlák, L Hunáková, J Duraj, M Grófová, B Chorváth |
Journal | Neoplasma
(Neoplasma)
Vol. 40
Issue 6
Pg. 337-40
( 1993)
ISSN: 0028-2685 [Print] Slovakia |
PMID | 7507222
(Publication Type: Journal Article)
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Chemical References |
- Antigens, CD
- CD59 Antigens
- Cytokines
- Membrane Glycoproteins
- Tretinoin
- Calcitriol
- Tetradecanoylphorbol Acetate
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Topics |
- Antigens, CD
(biosynthesis)
- Breast Neoplasms
(immunology, pathology)
- CD59 Antigens
- Calcitriol
(pharmacology)
- Carcinoma
(immunology, pathology)
- Cell Membrane
(immunology)
- Cytokines
(pharmacology)
- Down-Regulation
(drug effects)
- Electrophoresis, Polyacrylamide Gel
- Female
- Flow Cytometry
- Fluorescent Antibody Technique
- Glioma
(immunology, pathology)
- Humans
- Leukemia, Myeloid
(immunology, pathology)
- Leukemia, Promyelocytic, Acute
(immunology, pathology)
- Membrane Glycoproteins
(biosynthesis)
- Ovarian Neoplasms
(immunology, pathology)
- Tetradecanoylphorbol Acetate
(pharmacology)
- Tretinoin
(pharmacology)
- Tumor Cells, Cultured
- Up-Regulation
(drug effects)
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