Abstract |
In a randomised double-blind study, nimesulide 100mg twice daily for 8 days was compared with placebo in the treatment of 60 patients with ankle sprain. On day 4, three nimesulide-treated patients discontinued treatment because of resolution of their symptoms, whereas 11 patients in the placebo group discontinued as a result of worsening symptoms. A significantly greater reduction in pain, functional impairment and swelling was observed with nimesulide compared with placebo; moreover, the time to improvement was significantly shorter with the active treatment. The overall evaluation of efficacy favoured nimesulide over placebo (p < 0.001). Both medications were well tolerated, with 5 patients reporting mild gastralgia (4 treated with nimesulide and 1 with placebo), while 1 placebo-treated patient reported a mild gastrointestinal disturbance. These results suggest that nimesulide is an effective treatment for the short term management of post-traumatic pain states.
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Authors | R L Dreiser, D Riebenfeld |
Journal | Drugs
(Drugs)
Vol. 46 Suppl 1
Pg. 183-6
( 1993)
ISSN: 0012-6667 [Print] New Zealand |
PMID | 7506167
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Sulfonamides
- nimesulide
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Topics |
- Adolescent
- Adult
- Aged
- Ankle Injuries
(drug therapy)
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Sprains and Strains
(drug therapy)
- Sulfonamides
(therapeutic use)
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