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Identification of the genetic locus for keratosis palmaris et plantaris on chromosome 17 near the RARA and keratin type I genes.

Abstract
Familial keratosis palmaris et plantaris (KPPF) is characterized by extreme keratinization and desquamation of the skin of the palmar and plantar surfaces of the hands and feet. We have mapped the causative genetic defect to an 8 cM interval on 17q12-24 in or close to the acidic keratin (type I) gene cluster. We show that KPPF co-segregates with a rare, high molecular weight allele of an insertion-deletion polymorphism in the C-terminal coding region of the keratin 10 gene (Z = 8.36 at theta = 0.00) and segrates as a true autosomal dominant trait. Some pedigrees with familial hyperkeratosis of the palms and soles have co-inherited diseases such as congenital malformations and familial cancers. Our analysis provide a region which should be investigated for contiguous gene syndromes in such pedigrees.
AuthorsE I Rogaev, E A Rogaeva, E K Ginter, G I Korovaitseva, L A Farrer, A B Shlensky, A N Pritkov, V N Mordovtsev, P H St George-Hyslop
JournalNature genetics (Nat Genet) Vol. 5 Issue 2 Pg. 158-62 (Oct 1993) ISSN: 1061-4036 [Print] United States
PMID7504553 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • RARA protein, human
  • Receptors, Retinoic Acid
  • Retinoic Acid Receptor alpha
  • Keratins
  • DNA
Topics
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 17
  • DNA
  • DNA Mutational Analysis
  • Female
  • Genotype
  • Homozygote
  • Humans
  • Keratins (genetics)
  • Keratoderma, Palmoplantar (genetics)
  • Male
  • Molecular Sequence Data
  • Pedigree
  • Phenotype
  • Receptors, Retinoic Acid (genetics)
  • Retinoic Acid Receptor alpha

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