[Experimental pulmonary metastasis of Chinese hamster mesenchymal chondrosarcoma cell lines].

Abstract

Pulmonary metastases of chinese hamster mesenchymal chondrosarcoma cell lines, MCS-1 (undifferentiated type) and MCS-8 (differentiated type), were examined by intravenous transplantation into athymic nude mice. The incidence of pulmonary metastasis of MCS-1 was 100% and that of MCS-8 was 33% at the 23rd day after transfer. Mean number of metastatic nodules in the lung was 41 in the former and only 3 in the latter. Mean survival time of mice with MCS-1 injection (5 x 10(4) cells) was 27 days and that with MCS-8 (5 x 10(4) cells) was 48 days after transfer. At the 42nd day after transfer of MCS-8, however, the incidence of pulmonary metastasis was 100%. These data suggest that the tumor growth rate in the metastatic lesion, as well as the affinity to the target organ, is very important for evaluation of experimental metastasis.

• Authors: N Fujisawa, N L Sato, T Motoyama
• Journal: Experimental animals (Exp Anim) Vol. 43 Issue 5 Pg. 761-4 (Oct 1995) ISSN: 1341-1357 [Print] Japan
• PMID: 7498344 (Publication Type: English Abstract, Journal Article)

Topics

• Animals
• Bone Neoplasms (pathology)
• Chondrosarcoma, Mesenchymal (pathology, secondary)
• Cricetinae
• Cricetulus
• Female
• Lung Neoplasms (pathology, secondary)
• Male
• Mice
• Mice, Nude
• Neoplasm Transplantation
• Tumor Cells, Cultured