Levels of circulating fibronectin receptor in adult and pediatric patients with human immunodeficiency virus type 1 infection.

Abstract

We found a significant increase in fibronectin receptor (FNR) levels in the sera of adult human immunodeficiency virus type 1 (HIV-1)-infected patients, especially in those with AIDS (1,026.9 +/- 583.9 ng/ml; P < 0.0001). In contrast, AIDS patients with neurologic disorders and HIV-1-seropositive patients showed normal levels of FNR in serum. In addition, HIV-1-infected children showed increased levels of FNR in serum (824.4 +/- 333.5 ng/ml; P = 0.03). We suggest that an increase of FNR levels in AIDS patients is related to enhanced expression of FNR on HIV-1-infected cells.

• Authors: D Torre, C Zeroli, A Pugliese, M Giola, G Ferrario, G Bonetta, M Issi, R Martegani, F Speranza, G P Fiori
• Journal: Clinical and diagnostic laboratory immunology (Clin Diagn Lab Immunol) Vol. 1 Issue 3 Pg. 348-50 (May 1994) ISSN: 1071-412X [Print] United States
• PMID: 7496974 (Publication Type: Journal Article)

Chemical References

• Receptors, Fibronectin

Topics

• Acquired Immunodeficiency Syndrome (immunology)
• Adolescent
• Adult
• Child
• Child, Preschool
• Female
• HIV Infections (blood, immunology)
• HIV-1 (immunology)
• Humans
• Infant
• Male
• Middle Aged
• Receptors, Fibronectin (analysis, physiology)