Abstract |
The tremendous chemical potential of the highly conjugated double bonds in carotenoids has driven research into their protective role in cardiovascular disease development. Prevention of low-density-lipoprotein oxidation and reduction of oxidative stress at the plaque formation are popular hypotheses underlying this research. Many epidemiologic studies have examined relations between beta-carotene exposure and cardiovascular disease risk. These studies used different measures to determine carotenoid exposure: semiquantitative food-frequency questionnaires, carotenoid concentrations in serum taken before the onset of disease and analyzed after diagnosis, and carotenoid concentrations in adipose tissue. Although the epidemiologic evidence is consistent with a protective association between beta-carotene and cardiovascular disease, findings from the first single intervention trial conducted in a large free-living population cast doubts on the utility of beta-carotene for all high-risk populations. Beta-Carotene may only represent a marker of dietary behavior conductive to lower risk of cardiovascular disease. Research on other carotenoids is needed.
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Authors | L Kohlmeier, S B Hastings |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 62
Issue 6 Suppl
Pg. 1370S-1376S
(12 1995)
ISSN: 0002-9165 [Print] United States |
PMID | 7495233
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
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Chemical References |
- Antioxidants
- beta Carotene
- Carotenoids
- Ethanol
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Topics |
- Antioxidants
(administration & dosage)
- Cardiovascular Diseases
(prevention & control)
- Carotenoids
(administration & dosage, blood)
- Ethanol
(adverse effects)
- Humans
- Smoking
(blood)
- beta Carotene
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