Susceptibility of Acanthamoeba castellanii to contact lens disinfecting solutions.

Abstract

A corneal isolate of Acanthamoeba castellanii was exposed to commercial contact lens disinfecting solutions containing hydrogen peroxide, benzalkonium chloride, polyaminopropyl biguanide, polyquaternium 1, and chlorhexidine-thimerosal. The minimum trophozoite amebicidal concentration and exposure times required to kill trophozoites and cysts were determined. Solutions containing hydrogen peroxide or chlorhexidine-thimerosal were active against both trophozoites and cysts. The benzalkonium chloride-based solution was effective only against trophozoites. Solutions containing polyaminopropyl biguanide or polyquaternium 1 were completely ineffective. The need for adequate exposure times must be stressed.

• Authors: S Zanetti, P L Fiori, A Pinna, S Usai, F Carta, G Fadda
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 39 Issue 7 Pg. 1596-8 (Jul 1995) ISSN: 0066-4804 [Print] United States
• PMID: 7492111 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contact Lens Solutions

Topics

• Acanthamoeba (drug effects)
• Animals
• Contact Lens Solutions (pharmacology)
• Kinetics
• Microbial Sensitivity Tests