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Results of single-agent and combination chemotherapy for advanced soft tissue sarcomas. Implications for decision making in the clinic.

Abstract
Cytotoxic chemotherapy remains the principal modality of treating advanced or unresectable sarcomas of soft tissue. Certain drugs, such as doxorubicin and ifosfamide, are able to induce clinically useful antitumor effects as single agents, and combination chemotherapy regimens have been tested based upon these results. This article summarizes the results of single agent and combination chemotherapy trials for soft tissue sarcomas.
AuthorsG D Demetri, A D Elias
JournalHematology/oncology clinics of North America (Hematol Oncol Clin North Am) Vol. 9 Issue 4 Pg. 765-85 (Aug 1995) ISSN: 0889-8588 [Print] United States
PMID7490240 (Publication Type: Journal Article, Review)
Chemical References
  • Antineoplastic Agents
  • Vincristine
  • Dacarbazine
  • Doxorubicin
  • Cyclophosphamide
  • Mesna
  • Ifosfamide
Topics
  • Antineoplastic Agents (therapeutic use)
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Chemotherapy, Adjuvant
  • Clinical Trials as Topic
  • Combined Modality Therapy
  • Cyclophosphamide (administration & dosage)
  • Dacarbazine (administration & dosage)
  • Doxorubicin (administration & dosage, therapeutic use)
  • Humans
  • Ifosfamide (administration & dosage, therapeutic use)
  • Mesna (administration & dosage)
  • Randomized Controlled Trials as Topic
  • Salvage Therapy
  • Sarcoma (drug therapy, radiotherapy, surgery)
  • Soft Tissue Neoplasms (drug therapy, radiotherapy, surgery)
  • Treatment Outcome
  • Vincristine (administration & dosage)

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