Skeletal muscle metabolic abnormalities exist in chronic
heart failure. The influence of physical training on muscle metabolism after
myocardial infarction was studied in a rat model. 31P magnetic resonance spectroscopy and
enzyme assays were performed in Wistar rats 12 weeks after coronary artery
ligation. Infarcted rats were allocated randomly to either 6 weeks of training or non-training. Spectra were collected from the calf muscles during sciatic nerve stimulation at 2 Hz. Fibre typing and enzymatic assays were performed on the muscles of the contralateral non stimulated leg. Post-mortem rats were also divided into severe and moderate
heart failure according to the lung weight per
body weight. At 200 g twitch tension,
phosphocreatine and pH were found to be significantly lower in the non-trained severe
heart failure group compared with the other groups.
Phosphocreatine recovery half-time was significantly longer in the non-trained group with severe
heart failure and correlated with the
citrate synthase activity in the muscle. The training did not induce a change in the
enzyme activities in the infarcted animals with moderate
heart failure but did correct the lower
citrate synthase activity in the non-trained severe
heart failure animals. This normalization of muscle metabolism was achieved by training without any change in calf muscle mass, making
atrophy unlikely to be the sole cause of the metabolic changes in
heart failure. Training in rats with severe
heart failure can reverse the abnormalities of skeletal muscle metabolism, implicating decreased physical activity in the aetiology of these changes.