Abstract | OBJECTIVE: MATERIAL AND METHODS: RESULTS: Parkinsonian patients had significantly decreased values of csf NE and DOPAC, the strong relationship between plasma and csf NE was disrupted and neither was there any age related increase of plasma NE. In l-DOPA treated patients plasma DA and DOPA concentrations were raised and csf DOPAC values were inversely related to severity of disease (Hoehn and Yahr score). Csf E concentrations were also reduced in parkinsonian patients whereas csf DA concentrations were unchanged. Csf DOPA concentrations were insignificantly decreased in parkinsonian patients. CONCLUSIONS: These results point towards a diffuse neuronal dysfunction in Parkinson's disease and indicate that lumbar csf NE and csf DOPAC are of central nervous origin.
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Authors | E Eldrup, P Mogensen, J Jacobsen, H Pakkenberg, N J Christensen |
Journal | Acta neurologica Scandinavica
(Acta Neurol Scand)
Vol. 92
Issue 2
Pg. 116-21
(Aug 1995)
ISSN: 0001-6314 [Print] Denmark |
PMID | 7484057
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 3,4-Dihydroxyphenylacetic Acid
- Levodopa
- Dihydroxyphenylalanine
- Dopamine
- Norepinephrine
- Epinephrine
|
Topics |
- 3,4-Dihydroxyphenylacetic Acid
(blood, cerebrospinal fluid)
- Adult
- Aged
- Dihydroxyphenylalanine
(blood, cerebrospinal fluid)
- Dopamine
(blood, cerebrospinal fluid)
- Epinephrine
(blood, cerebrospinal fluid)
- Female
- Humans
- Levodopa
(therapeutic use)
- Lumbosacral Region
- Male
- Middle Aged
- Norepinephrine
(blood, cerebrospinal fluid)
- Parkinson Disease
(blood, cerebrospinal fluid, drug therapy)
- Severity of Illness Index
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