[Role of platelet activating factor on the formation of ischemic colitis].

Abstract

Role of platelet activating factor (PAF) on the formation of rat ischemic colitis was investigated. High incidence of the formation of ischemic colitis was observed after ligation of marginal vessels of the rat with stricture of the rectum, however, administration of PAF-inhibitor (TCV) decreased incidence of the lesion. Only the lesion in the mucosa occurred after clamping of the marginal vessels of the rat with stricture of the rectum and administration of TCV did not affect the incidence of the lesion. In conclusion, the etiological involvement of PAF on deterioration of the ischemic colitis was suspected.

• Authors: H Idei, Y Nagahata, Y Saitoh
• Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology (Nihon Shokakibyo Gakkai Zasshi) Vol. 92 Issue 10 Pg. 1734-42 (Oct 1995) ISSN: 0446-6586 [Print] Japan
• PMID: 7474465 (Publication Type: English Abstract, Journal Article)

Chemical References

• Platelet Activating Factor

Topics

• Animals
• Colitis, Ischemic (etiology)
• Male
• Platelet Activating Factor (antagonists & inhibitors, physiology)
• Rats
• Rats, Wistar