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[Orally active vasodilators in the management of chronic treatment-resistant cardiac failure (author's transl)].

Abstract
The acute haemodynamic effects of 40 mg isosorbide dinitrate (10 subjects), 4 mg prazosin (20 subjects) and 50 mg dihydralazine (8 subjects) were compared in 24 patients with the clinical picture of chronic therapy-resistant cardiac failure (NY Heart Association stages III-IV). There was a fall in left-ventricular filling pressure of about 15% and right-atrial mean pressure of 21 and 24%, respectively, with isosorbide dinitrate and prazosin, while there was no change with dihydralazine. Cardiac output rose by 23% with dihydralazine and 20% with prazosin, but remained unchanged with isosorbide dinitrate. These data indicate that a reduction in pulmonary and systemic-venous congestion due to chronic decompensated cardiac failure can be achieved with isosorbide dinitrate and prazosin, while cardiac output can be improved only with prazosin and dihydralazine.
AuthorsA Wirtzfeld, G Klein, F C Himmler, G Schmidt, I Kutschera, E Sauer
JournalDeutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 105 Issue 40 Pg. 1379-83 (Oct 3 1980) ISSN: 0012-0472 [Print] GERMANY, WEST
Vernacular TitleOral wirksame Vasodilatoren bei der chronischen therapieresistenten Herzinsuffizienz. Wirkungsvergleich von Isosorbiddinitrat, Prazosin und Dihydralazin.
PMID7449633 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Quinazolines
  • Hydralazine
  • Isosorbide Dinitrate
  • Dihydralazine
  • Prazosin
Topics
  • Adult
  • Aged
  • Dihydralazine (therapeutic use)
  • Heart Failure (drug therapy)
  • Hemodynamics (drug effects)
  • Humans
  • Hydralazine (analogs & derivatives)
  • Isosorbide Dinitrate (therapeutic use)
  • Middle Aged
  • Prazosin (therapeutic use)
  • Quinazolines (therapeutic use)

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