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Comparison of sex steroid receptor analyses and carcinoembryonic antigen with clinical response to hormone therapy.

Abstract
This study corroborates previous reports which suggested the efficacy of estrogen receptor (ER) analysis in predicting responses of patients with metastatic mammary carcinoma to hormonal therapeutic manipulation. The predictive value of multiconcentration titration and sucrose density gradient analyses of ERs and progesterone receptors (PRs) are compared. The predictive value of ER analyses can be improved by the discrimination of 8S versus 4S binding species or by the use of PR analysis in combination with ER analysis. The tumor-associated antigen, carcinoembryonic antigen (CEA), is evolving as an important quantitative aid in evaluating the clinical responses to patients receiving hormonal therapy.
AuthorsK S McCarty Jr, C Cox, J S Silva, B H Woodard, J A Mossler, D E Haagensen Jr, T K Barton, K S McCarty Sr, S A Wells Jr
JournalCancer (Cancer) Vol. 46 Issue 12 Suppl Pg. 2846-50 (Dec 15 1980) ISSN: 0008-543X [Print] United States
PMID7448731 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Carcinoembryonic Antigen
  • Estrogen Antagonists
  • Progestins
  • Receptors, Estrogen
  • Receptors, Progesterone
  • Fluoxymesterone
Topics
  • Adrenalectomy
  • Breast Neoplasms (analysis, therapy)
  • Carcinoembryonic Antigen (analysis)
  • Castration
  • Centrifugation, Density Gradient
  • Estrogen Antagonists (therapeutic use)
  • Female
  • Fluoxymesterone (therapeutic use)
  • Humans
  • Hypophysectomy
  • Neoplasm Metastasis
  • Progestins (therapeutic use)
  • Receptors, Estrogen (analysis)
  • Receptors, Progesterone (analysis)

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