Abstract |
In a comparative kinetic study of the serum concentrations of two penicillin complexes--medium-long-acting ( benethamine penicillin) and long-acting ( benzathine bipenicillin)--after a single injection in young adults and elderly people, the following results were confirmed statistically: (a) age was a major factor in the variations in serum penicillin concentrations and in their persistence in the serum; (b) the penicillin was absorbed faster in young than in elderly subjects even when a long-acting complex was used; (c) serum concentrations below the level regarded as lethal for treponemes appeared much earlier and more frequently in young than in old people; and (d) the bioequivalence between penicillin preparations could not be estimated solely for the number of units of the agent used but from the bioavailability of the chosen formulation. Thus a uniform and standard penicillin dosage allowing no safety margin may help in the superficial healing of a syphilitic chancre or the resolution of a roseola but it will certainly be insufficient to kill Treponema pallidum. It seems essential therefore to provide an antibiotic cover at high dosage over a long period of time.
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Authors | P Collart, M Poitevin, A Milovanovic, A Herlin, J Durel |
Journal | The British journal of venereal diseases
(Br J Vener Dis)
Vol. 56
Issue 6
Pg. 355-62
(Dec 1980)
ISSN: 0007-134X [Print] England |
PMID | 7448577
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Penicillins
- benethamine penicillin
- Penicillin G
- Penicillin G Benzathine
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Topics |
- Adult
- Age Factors
- Aged
- Biological Availability
- Drug Administration Schedule
- Female
- Humans
- Kinetics
- Male
- Middle Aged
- Penicillin G
(administration & dosage, analogs & derivatives)
- Penicillin G Benzathine
(administration & dosage)
- Penicillins
(blood)
- Syphilis
(drug therapy)
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