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Immunoblastic sarcoma after thymus epithelial graft in an immunodeficient child.

Abstract
A 3 1/2-year-old girl with severe combined immunodeficiency received a thymus epithelial graft. After transient clinical and in vitro immunologic improvement, she developed fever, lung infiltrates and, terminally, massive gastrointestinal bleeding only 2 1/2 months after transplantation. Autopsy revealed widespread immunoblastic sarcoma involving both transplantation sites in the mesentery and thigh, lymph nodes, lung, liver, spleen and gastrointestinal tract. This B cell lymphoma was likely induced by the grafted thymus epithelium.
AuthorsM Dictor
JournalHistopathology (Histopathology) Vol. 4 Issue 6 Pg. 661-8 (Nov 1980) ISSN: 0309-0167 [Print] England
PMID7439894 (Publication Type: Case Reports, Journal Article)
Topics
  • Child, Preschool
  • Epithelium (transplantation, ultrastructure)
  • Female
  • Humans
  • Immunologic Deficiency Syndromes (surgery)
  • Liver (pathology)
  • Lymphoma (etiology, pathology)
  • Necrosis
  • Spleen (pathology)
  • Thymus Gland (transplantation, ultrastructure)
  • Transplantation, Homologous

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