Mepirizole, a non-steroidal antiinflammatory compound, its ulcerogenicity and inhibitory action on lesions induced by acidic antiinflammatory agents in the rat stomach.

Abstract

Gastric lesions were produced in rats by the administration for 2 weeks of 300 mg/kg/day of mepirizole, a basic non-steroidal antiinflammatory compound. Although the single administration of 200 mg/kg of mepirizole had no effect, the addition of water-immersion stress for one hour induced lesions not only in the corpus but also in the pyloric antrum. The administration of 250 mg/kg of mefenamic acid, an acidic non-steroidal antiinflammatory compound (insufficient for producing gastric lesions at this dose alone) with the addition of one hour of water-immersion stress induced gastric lesions. The addition of 200 mg/kg of mepirizole reduced the ulcer index from 8.1 to 4.7 in the corpus and from 4 to 0.5 in the pyloric antrum. It is suggested that basic antiinflammatory compounds inhibit gastric lesions induced by combination of acidic antiinflammatory compounds and water-immersion stress.

• Authors: K Kobayashi, S Chono, H Yamada
• Journal: Gastroenterologia Japonica (Gastroenterol Jpn) Vol. 15 Issue 5 Pg. 427-32 ( 1980) ISSN: 0435-1339 [Print] Japan
• PMID: 7439616 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Pyrazoles
• Mefenamic Acid
• Epirizole

Topics

• Animals
• Anti-Inflammatory Agents (administration & dosage)
• Dose-Response Relationship, Drug
• Epirizole (administration & dosage)
• Fibrinolysis
• Gastric Mucosa (physiology)
• Male
• Mefenamic Acid (administration & dosage, antagonists & inhibitors)
• Pyrazoles (administration & dosage)
• Rats
• Stomach Ulcer (chemically induced)
• Stress, Physiological (complications)