Effect of acyclovir on acute and latent herpes simplex virus infections in the rabbit.

Abstract

Acyclovir, a new potent antiviral drug, was used to treat herpes simplex virus (HSV) infection in the rabbit ocular model. Acyclovir (3% ointment) used topically one to five times a day on acute ocular HSV infection gave beneficial results as measured by a reduction in corneal involvement, conjunctivitis, iritis, and corneal clouding. Topical treatment did not prevent the establishment of latent HSV infection. Intravenous acyclovir used two times a day (50 mg/kg) on rabbits with latent HSV infection appeared to suppress HSV in the nervous system but did not eradicate established latent HSV infection.

• Authors: M D Trousdale, E C Dunkel, A B Nesburn
• Journal: Investigative ophthalmology & visual science (Invest Ophthalmol Vis Sci) Vol. 19 Issue 11 Pg. 1336-41 (Nov 1980) ISSN: 0146-0404 [Print] United States
• PMID: 7429768 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antiviral Agents
• Guanine
• Acyclovir

Topics

• Acyclovir
• Administration, Topical
• Animals
• Antiviral Agents (therapeutic use)
• Disease Models, Animal
• Guanine (analogs & derivatives, therapeutic use)
• Injections, Intravenous
• Keratitis, Dendritic (drug therapy)
• Male
• Rabbits