Response of psoriatic nails to oral photochemotherapy.

Abstract

Ten patients with generalized psoriasis, which included nail involvement, were treated with total-body oral photochemotherapy. A combination of methoxsalen and high-intensity ultraviolet A radiation was employed and its therapeutic efficacy in nail psoriasis ascertained. Among the ten patients, there were 26 instances of the following nail signs: pitting, onycholysis, "oil drop" change, subungual hyperkeratosis, nail-plate crumbling, proximal nail-fold psoriasis, and onychorrhexis. Of the 26, eighteen improved by 50% or more. Only pitting failed to respond to therapy in all of the eight patients who had this change.

• Authors: J L Marx, R K Scher
• Journal: Archives of dermatology (Arch Dermatol) Vol. 116 Issue 9 Pg. 1023-24 (Sep 1980) ISSN: 0003-987X [Print] United States
• PMID: 7416754 (Publication Type: Journal Article)

Chemical References

• Methoxsalen

Topics

• Humans
• Methoxsalen (administration & dosage, therapeutic use)
• Nail Diseases (drug therapy)
• Photochemotherapy
• Psoriasis (drug therapy)
• Ultraviolet Rays