Renal function in rats with acute medullary injury.

Abstract

Acute, reversible renal failure affecting primarily medullary structures, was produced by feeding rats a diet containing 5% oxonic acid and 2.5% uric acid for 7 days. Inulin clearance and selected tubular transport processes were studied and compared to controls. At the time of maximal renal injury, inulin clearance was reduced to 40% of control values, in association with a 60% reduction in urine concentrating ability, a 50% reduction in potassium excretion and a 56% reduction in ammonium excretion. During a 7-day recovery period, inulin clearance increased to 70% of control and potassium excretion returned to normal while the other tubular transport functions remained impaired. Thus, in acute renal failure, tubular functional impairments may recover at different rates.

• Authors: E A Brown, A S Kliger, J P Hayslett, F O Finkelstein
• Journal: Nephron (Nephron) Vol. 26 Issue 2 Pg. 64-8 ( 1980) ISSN: 1660-8151 [Print] Switzerland
• PMID: 7412961 (Publication Type: Journal Article)

Chemical References

• Uric Acid
• Oxonic Acid
• Inulin
• Potassium
• Calcium

Topics

• Acute Kidney Injury (etiology, physiopathology)
• Animals
• Calcium (urine)
• Diet
• Disease Models, Animal
• Glomerular Filtration Rate
• Hydrogen-Ion Concentration
• Inulin
• Kidney Medulla (physiopathology)
• Kidney Tubules (physiopathology)
• Male
• Oxonic Acid
• Potassium (urine)
• Rats
• Uric Acid