Abstract |
The effects of 2 mg/kg/day theophylline (serum concentrations, 2.9 to 4.7 micrograms/ml) on metabolic rate were observed in 11 premature infants with severe idiopathic apnea of prematurity. Oxygen consumption (VO2/kg) increased 25% from 6.5 +/- 0.4 (SEM) to 8.1 +/- 0.6 cc/min/kg after 24 to 48 hr of therapy. Respiratory quotient did not change. Apnea and bradycardia decreased from 8.6 +/- 1.4 to 1.6 +/- 0.5 episodes/hr and 4.4 +/- 1.1 to 1.2 +/- 0.4 episodes/hr, respectively. This dose of theophylline is effective in idiopathic apnea of prematurity and acts as a metabolic stimulant. In the premature infant, theophylline-induced increases in VO2 may be a result of changes in the sleep state.
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Authors | R L Milsap, A N Krauss, P A Auld |
Journal | Clinical pharmacology and therapeutics
(Clin Pharmacol Ther)
Vol. 28
Issue 4
Pg. 536-40
(Oct 1980)
ISSN: 0009-9236 [Print] United States |
PMID | 7408413
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Apnea
(drug therapy, metabolism)
- Female
- Humans
- Infant, Newborn
- Infant, Premature, Diseases
(drug therapy, metabolism)
- Male
- Oxygen Consumption
(drug effects)
- Theophylline
(administration & dosage, pharmacology, therapeutic use)
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