Abstract |
The pharmacokinetics and metabolism of N-nitrosomethyl- benzylamine, N-nitroso[methyl-14C] benzylamine, and N-nitrosomethyl[benzyl-7-14C] amine were studied in male Sprague-Dawley rats, and a major urinary metabolite was identified. N-Nitrosomethylbenzylamine (4.7 mg/kg body weight i.p.) was distributed throughout extracellular water and cleared from the whole blood by metabolism with a half-life of 66 min. Less than 1% of the administered dose of N-nitrosomethylbenzylamine (4.7 mg/kg i.p. or 3.3 mg/kg intragastric intubation) was excreted and expired as the parent compound. In the 24-hr period following injection of N-nitroso[methyl-14C1benzylamine (3.4 mg, 1 mCi/kg i.p.), 46% of the radioactivity administered was expired with a half-life of 2.1 hr. In contrast, 81% of the radioactivity from a dose of N-nitrosomethyl[benzyl-7-14C1amine (2.4 mg, 1 mCi/kg i.p.) was excreted in the urine with a half-life of 4.2 hr. Hippuric acid accounted for 80% of the radioactivity recovered in the urine.
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Authors | P L Kraft, P L Skipper, S R Tannenbaum |
Journal | Cancer research
(Cancer Res)
Vol. 40
Issue 8 Pt 1
Pg. 2740-2
(Aug 1980)
ISSN: 0008-5472 [Print] United States |
PMID | 7388824
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Benzyl Compounds
- nitrosobenzylmethylamine
- Dimethylnitrosamine
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Topics |
- Animals
- Benzyl Compounds
(metabolism, urine)
- Diet
- Dimethylnitrosamine
(analogs & derivatives, metabolism, urine)
- Feces
(chemistry)
- Male
- Metabolic Clearance Rate
- Rats
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