Abstract |
Radioimmunologically estimated diurnal profiles of 17-hydroxyprogesterone (17-OHP) showed clearly increased values in 15 patients with adrenogenital syndrome aged 9-19 years who had been treated for at least 4 1/2 years with cortisol. Increases were pronounced in the morning: at 8 hours 58.6 nmol/l, at 12 hours 22.2 nmol/l, at 18 hours 23.7 nmol/l on average. By changing cortisol medication, in particular due to split doses, morning 17-OHP peak values could be lowered and the whole daily profile could be improved: at 8 hours 17.9 nmol/l, at 12 hours 9.3 nmol/l, at 18 hours 8.1 nmol/l on average. The total cortisol dosage had to be increased only marginally from an average of 26.7 to 30 mg/m2 body surface, however, the evening dosage was increased from 20% to 38% on average of the total dose. Measurement of serum 17-OHP diurnal profile is thus advantageous in treatment of adrenogenital syndrome with cortisol when compared to values obtained from 24-hour urine collections.
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Authors | E Nieschlag, H Wenner, H Breu, E J Wickings, G Schellong |
Journal | Deutsche medizinische Wochenschrift (1946)
(Dtsch Med Wochenschr)
Vol. 105
Issue 17
Pg. 600-3
(Apr 25 1980)
ISSN: 0012-0472 [Print] Germany |
Vernacular Title | Adrenogenitales Syndrom. Therapeutische Einstellung anhand des Tagesprofils des 17-Hydroxyprogesterons im Serum. |
PMID | 7371512
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Hydroxyprogesterones
- Hydrocortisone
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Topics |
- Adolescent
- Adrenal Hyperplasia, Congenital
(blood, drug therapy)
- Adult
- Child
- Female
- Humans
- Hydrocortisone
(administration & dosage, therapeutic use)
- Hydroxyprogesterones
(blood)
- Male
- Radioimmunoassay
- Time Factors
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