[Treatment of stomach ulcer and of Zollinger-Ellison syndrome with cimetidine].

Abstract

The treatment of gastric ulcer by the H2-receptor-antagonist Cimetidine results in an ulcer healing rate of 60 to 80% during a 4 to 6 weeks therapy cure. In most studies Cimetidine is superior to placebo or equipotent to a high dose antacid regimen, the latter being accepted to be of beneficial effect on ulcer healing. In the Zollinger-Ellison-syndrome Cimetidine inhibits largely gastric acid hypersecretion and represents for the first time a true alternative to total gastrectomy.

• Authors: H Brunner
• Journal: Acta medica Austriaca (Acta Med Austriaca) Vol. 5 Issue 2 Pg. 36-40 ( 1978) ISSN: 0303-8173 [Print] Austria
• Vernacular Title: Die Behandlung des Ulcus ventriculi und des Zollinger-Ellison-Syndroms mit Cimetidin.
• PMID: 735716 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Antacids
• Gastrins
• Guanidines
• Placebos
• Cimetidine
• Carbenoxolone

Topics

• Antacids (therapeutic use)
• Carbenoxolone (therapeutic use)
• Cimetidine (therapeutic use)
• Double-Blind Method
• Gastric Juice (metabolism)
• Gastric Mucosa (drug effects)
• Gastrins (metabolism)
• Guanidines (therapeutic use)
• Humans
• Placebos
• Stomach Ulcer (drug therapy)
• Zollinger-Ellison Syndrome (drug therapy)