Abstract |
Cell death, inflammation, and repair in rabbits' aortas and pulmonary arteries were observed at 3-, 7-, and 10-day periods after the intravenous injection of oxygenated sterols. Thus, oxygenated sterols, not cholesterol, may play the primary role in arterial wall injury and lesion development.
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Authors | H Imai, N T Werthessen, V Subramanyam, P W LeQuesne, A H Soloway, M Kanisawa |
Journal | Science (New York, N.Y.)
(Science)
Vol. 207
Issue 4431
Pg. 651-3
(Feb 08 1980)
ISSN: 0036-8075 [Print] United States |
PMID | 7352277
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Epoxy Compounds
- Ethers, Cyclic
- Hydroxycholesterols
- Lanosterol
- Cholesterol
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Topics |
- Animals
- Aorta
(drug effects)
- Blood Vessels
(drug effects, pathology)
- Cholesterol
(analogs & derivatives, toxicity)
- Epoxy Compounds
(toxicity)
- Ethers, Cyclic
(toxicity)
- Female
- Hydroxycholesterols
(toxicity)
- Lanosterol
(analogs & derivatives, toxicity)
- Male
- Necrosis
- Oxidation-Reduction
- Pulmonary Artery
(drug effects)
- Rabbits
- Structure-Activity Relationship
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