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Angiotoxicity of oxygenated sterols and possible precursors.

Abstract
Cell death, inflammation, and repair in rabbits' aortas and pulmonary arteries were observed at 3-, 7-, and 10-day periods after the intravenous injection of oxygenated sterols. Thus, oxygenated sterols, not cholesterol, may play the primary role in arterial wall injury and lesion development.
AuthorsH Imai, N T Werthessen, V Subramanyam, P W LeQuesne, A H Soloway, M Kanisawa
JournalScience (New York, N.Y.) (Science) Vol. 207 Issue 4431 Pg. 651-3 (Feb 08 1980) ISSN: 0036-8075 [Print] United States
PMID7352277 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Epoxy Compounds
  • Ethers, Cyclic
  • Hydroxycholesterols
  • Lanosterol
  • Cholesterol
Topics
  • Animals
  • Aorta (drug effects)
  • Blood Vessels (drug effects, pathology)
  • Cholesterol (analogs & derivatives, toxicity)
  • Epoxy Compounds (toxicity)
  • Ethers, Cyclic (toxicity)
  • Female
  • Hydroxycholesterols (toxicity)
  • Lanosterol (analogs & derivatives, toxicity)
  • Male
  • Necrosis
  • Oxidation-Reduction
  • Pulmonary Artery (drug effects)
  • Rabbits
  • Structure-Activity Relationship

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