[Management of treatment-resistant hypertension: comparison of the antihypertensive effect of endralazine and minoxidil (author's transl)].

In 16 fo 20 patients with treatment-resistant hypertension endralazine, combined with beta-receptor blockers and diuretics, significantly lowered mean arterial blood pressure from 198/112 mmHg to 148/88 mmHg. The initial dose of endralazine was 2.5 mg three times daily. After this the dosage was increased, at the three to six-day intervals according to antihypertensive action and side effects, to a maximum of 50 mg daily in steps of 5.0--7.5 mg per dose. - In a second series of eleven additional patients with treatment-resistant renal hypertension the blood-pressure lowering effect of hydralazine and minoxidil was compared in an open cross-over trial. The result was in favour of hydralazine. Sodium and water retention was slightly less marked with endralazine. Sleep disorders, increased frequency of feeling cold, moderately severe flushing with red checks and feeling hot occurred but rarely with endralazine and regressed during the period of observation.
AuthorsJ Kindler, W M Glöckner, H G Sieberth, A Konrads, K A Meurer, V Schulz, P Vaith
JournalDeutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 106 Issue 37 Pg. 1176-81 (Sep 11 1981) ISSN: 0012-0472 [Print] Germany
Vernacular TitleBehandlung der therapieresistenten Hypertonie. Antihypertensive Wirksamkeit von Endralazin im Vergleich mit Minoxidil.
PMID7343274 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article)
Chemical References
  • Pyridazines
  • Pyrimidines
  • BQ 22-708
  • Minoxidil
  • Adolescent
  • Adult
  • Aged
  • Female
  • Humans
  • Hypertension (drug therapy)
  • Hypertension, Renal (drug therapy)
  • Male
  • Middle Aged
  • Minoxidil (therapeutic use)
  • Pyridazines (administration & dosage, adverse effects, therapeutic use)
  • Pyrimidines (therapeutic use)
  • Sleep Wake Disorders (chemically induced)

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