Immunologic studies before and after splenectomy in a patient with the Wiskott-Aldrich syndrome.

Abstract

Sequential studies of cellular and humoral immunity were conducted in an infant with the Wiskott-Aldrich syndrome prior to and after a splenectomy for uncontrollable hemorrhage. All measures of cellular immunity showed gradual improvement during the 8-month period after surgery. Serum isohemagglutinins, diphtheria and tetanus antibodies, and the percentage of immunoglobulin-bearing B cells did not change significantly from presplenectomy values. The serum IgE concentration declined from a high of 10,800 IU/ml at 1 month postsplenectomy to a low of 860 IU/ml at 5 months after surgery and the IgG concentration gradually decreased from a high of 1880 mg/dl presplenectomy to a low of 620 mg/dl 8 months later. The platelet count ranged from 64,000 to 206,000/mm3 for the first 6 months after splenectomy. It decreased precipitously 6.5 months after the operation; at the same time there was a marked rise in platelet-bound IgG antibody (PB-IgG). The PB-IgG declined rapidly following vincristine therapy and, after another rise, declined more gradually following steroid therapy.

• Authors: A P Knutsen, W F Rosse, T R Kinney, R H Buckley
• Journal: Journal of clinical immunology (J Clin Immunol) Vol. 1 Issue 1 Pg. 13-9 (Jan 1981) ISSN: 0271-9142 [Print] Netherlands
• PMID: 7334067 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Immunoglobulin G
• Vincristine

Topics

• Antibody Formation
• Blood Platelets (immunology)
• Follow-Up Studies
• Humans
• Immunity, Cellular
• Immunoglobulin G (biosynthesis)
• Infant
• Lymphocyte Activation
• Male
• Prospective Studies
• Rosette Formation
• Splenectomy
• Vincristine (therapeutic use)
• Wiskott-Aldrich Syndrome (drug therapy, immunology, therapy)